Deputy Dawg was the loyal but none-too-bright canine lawman of a backwoods Tennessee precinct, Creekmud Junction. The animals that live in the nearby swamp tend to give Deputy Dawg a hard time. Most of the trouble stems from Muskie Muskrat and his predilection of stealing eggs from the Sheriff's henhouse. Three incidental characters would be spun off from this show into their own. A little blue space alien would become Astronut, Mischa Mouse would become Macon Mouse for the theatrical Possible Possum series, and the Long Island Duckling would become Duckwood.
In its original run, two Deputy Dawg cartoons were shown with features from theatrical Terrytoons films in the middle. Some markets screened Deputy Dawg cartoons individually as part of locally hosted children's shows. The Deputy Dawg Show would be replayed on NBC in 1971 on Saturday mornings.